Data report
Logged in as: Mike Dewhirst, ABC Australia Pty Ltd
Always refresh your browser to see any changes: 2022-04-15 06:20:00 UTC
This report shows data used as input for categorisation plus generated information of possible interest to AICIS in the event of an audit.
Industrial chemical data |
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Trade or chemical name: | Amyl ethyl ether |
CAS name: | tert-Amyl ethyl ether |
Portfolio ID: | NIC1005242 |
Division | ABC Australia Pty Ltd - Operations |
Access status | Default - all identifying information (name, CAS etc) visible |
Physical state | Liquid |
Origin | Imported |
Information availability | Introducer does know the CAS number and CAS name for the introduced chemical |
CAS number | 919-94-8 |
AICIS listing | Searched for but not found |
CAS name | tert-Amyl ethyl ether |
IUPAC name | Not entered |
INCI name | Not entered |
Nano-material | No |
Nano-soluble | No |
Incidental nano-material | No |
UVCB substance | Not applicable |
UVCB substance description | Not applicable |
GM product | No |
Name of GM organism | Not applicable |
Biological chemical | No |
Biochemical | No |
Biocidal active | No |
Organotin | No |
UV filter | No |
Polyhalogenated organic | No |
Fully fluorinated carbons | No |
Highly branched organic | Not applicable |
Persistent | No |
Environment info required for AICIS: 05 Persistent bioaccumulative and toxic: Log Kow | 08 November 2021
A suitable in-silico prediction for partition coefficient of the chemical itself of log Kow <4.2 (that is not negated by a measured log Kow) or
a measured value from a study on the chemical or from suitable read-across information, conducted following an acceptable test guideline for partition coefficient for which log Kow <4.2
OECD Test 107: Partition Coefficient (n-octanol/water): Shake Flask Method OECD Test 117: Partition Coefficient (n-octanol/water), HPLC Method OECD Test 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method |
Readily biodegradable | No |
Bioconcentration factor | 38 BCF |
Bioaccumulation factor | Not entered |
Octanol/Water partition ratio | 3.15 |
Aqueous solubility | 3.92 |
CIH company | Not entered |
Information holder | Adrian Thomas
adrian@chemicalia.com ABC Australia Pty Ltd 1234567 Elsewhere Qld 4444 Australia |
International assessment | Not entered |
International health assessment | No |
Permission to use entire health assessment report | Not applicable |
International environment assessment | No |
Permission to use entire environment assessment report | Not applicable |
Rotterdam-Stockholm-Minamata | Not detected |
Formula | C₇H₁₆O |
2D structure | |
Chemical structure | Not entered |
Molecular weight | 116.2 g/mol |
EC No | Not entered |
ChemSpider ID | 12939 |
Standard InChIKey | KFRVYYGHSPLXSZ-UHFFFAOYSA-N (commonchemistry.cas.org)
KFRVYYGHSPLXSZ-UHFFFAOYSA-N (ChemSpider) |
Standard InChI | InChI=1S/C7H16O/c1-5-7(3,4)8-6-2/h5-6H2,1-4H3 (commonchemistry.cas.org)
InChI=1S/C7H16O/c1-5-7(3,4)8-6-2/h5-6H2,1-4H3 (ChemSpider) |
SMILES structure | CCC(C)(C)OCC (commonchemistry.cas.org)
CCC(C)(C)OCC (ChemSpider) |
1 Chemical volume |
|
Product name | Racing fuel |
End use scenario | Fuel, oil and related products |
End use | Gasoline or petrol |
Maximum end use concentration | 10 % |
Child or food contact | Neither |
Aerosolised during end use | No |
Any consumer end use | No |
No of items | Not entered |
Item unit weight | Not entered |
Product volume | 560 t |
Precise proportion | 10% m/m Amyl ethyl ether |
Chemical volume | 56 t |
Introduction |
|
Report ID | Not entered |
Exclusion | Not applicable |
Specified class | Not applicable |
Circumstances | Not applicable |
Introduction | Reported - low risk |
Total introduced | 56,000.0 kg |
Maximum concentration | 10 % |
Software revision | 0.9.60 |
5 Hazards |
|
H305 | H305 Aspiration hazard: Category 2: May be harmful if swallowed and enters airways |
H315 | H315 Skin corrosion/irritation: Category 2: Causes skin irritation |
H319 | H319 Serious eye damage/eye irritation: Category 2: Causes serious eye irritation |
H336 | H336 Specific target organ toxicity - single exposure: Category 3: May cause drowsiness or dizziness |
IC-R.S1.2.4.13 | IC-R.S1.2.4.13 Environmental pollutant: Aquatic: Industrial chemical (other than a polymer) that does not meet the criteria for ready biodegradability |
7 Synonyms |
|
.. aka .. | 2-Ethoxy-2-methylbutane |
.. aka .. | Butane, 2-ethoxy-2-methyl- |
.. aka .. | Ether, ethyl tert-pentyl |
.. aka .. | Ethyl 1,1-dimethylpropyl ether |
.. aka .. | Ethyl tert-amyl ether |
.. aka .. | Ethyl tert-pentyl ether |
.. aka .. | tert-Amyl ethyl ether |
10 Useful links |
|
AICIS assessment | https://www.industrialchemicals.gov.au/chemical-information/search-assessments?assessmentcasnumber=919-94-8 |
AICIS CAS Number search | https://www.industrialchemicals.gov.au/search-inventory?casnumber=919-94-8 If the CAS number is found this link will lead to the Inventory terms of listing. Otherwise it is most likely not listed |
AICIS checklist - Reported - low risk | https://www.industrialchemicals.gov.au/sites/default/files/2021-03/Reported%20checklist%20-%20Highest%20indicative%20risk%20for%20your%20introduction%20is%20low%20risk%20%5B516%20KB%5D_0.pdf The pdf file in this link will either download or display depending on your browser preferences |
AICIS Google search | https://www.google.com/search?q=919-94-8+site%3A.industrialchemicals.gov.au Google search of the AICIS website for existing documents containing this CAS number |
AICIS record keeping obligations - Reported - low risk | https://www.industrialchemicals.gov.au/business/reporting-and-record-keeping-obligations/record-keeping-obligations-reported-introductions/record-keeping-reported-introductions-highest-indicative-risk-low |
Attachment 13 - Racing Fuel 200 L Label Rear Panel | https://www.dropbox.com/s/vpabb599cz5w67o/Item%2028%20-%20Attachment%2013%20-%20Racing%20Fuel%20200%20L%20Label%20Rear%20Panel.pdf?dl=0 |
Attachment 15 - Racing Fuel 50 L Label Rear Panel | https://www.dropbox.com/s/wtnvkut04pj05kn/Item%2032%20-%20Attachment%2015%20-%20Racing%20Fuel%2050%20L%20Label%20Rear%20Panel.pdf?dl=0 |
Attachment 17 - Racing Fuel 20 L Label Rear Panel | https://www.dropbox.com/s/ejz0xrwa58irksb/Item%2036%20-%20Attachment%2017%20-%20Racing%20Fuel%2020%20L%20Label%20Rear%20Panel.pdf?dl=0 |
Attachment 8 - NICNAS Full Public Report on t-Amyl methyl ether (TAME) NA_878 | https://www.dropbox.com/s/p4x3drp51w75pef/Item%2018%20-%20Attachment%208%20-%20NICNAS%20Full%20Public%20Report%20on%20t-Amyl%20methyl%20ether%20%28TAME%29%20NA_878%20highlighted.pdf?dl=0 |
Attachment 9 - European Union Risk Assessment Report, Tert-Butyl Methyl Ether, 2002 | https://www.dropbox.com/s/k3l5s1xe7lrfwz4/Item%2020%20-%20Attachment%209%20-%20European%20Union%20Risk%20Assessment%20Report%2C%20Tert-Butyl%20Methyl%20Ether%2C%202002%20highlighted.pdf?dl=0 |
7 Notes |
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Environment info required for AICIS: 06 Very toxic to any aquatic life | 08 November 2021
Information on aquatic toxicity for all three trophic levels (fish, invertebrates and algae) from suitable in silico predictions on the chemical or in vivo studies on the chemical or from suitable read across information, conducted following acceptable test guidelines for aquatic toxicity, with the following results for all three trophic levels: - acute aquatic toxicity >1 mg/L (96 h LC50 (fish), or 48 h EC50 (invertebrates) or 72 or 96 h ErC50 (algae)), or - chronic aquatic toxicity NOEC or EC10 >0.1 mg/L (for chemicals that are not readily biodegradable)
OECD Test 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test OECD Test 202: Daphnia sp. Acute Immobilisation Test OECD Test 203: Fish, Acute Toxicity Test OECD Test 210: Fish, Early-life Stage Toxicity Test OECD Test 211: Daphnia magna Reproduction Test |
Health info required for AICIS: 05 Genetic toxicity: GRAS substances | 08 November 2021
Information to demonstrate that the chemical is included on the Select Committee on GRAS Substances (SCOGS) Database as a Type 1 conclusion, and that the human health exposure expected from the industrial use of the chemical is no higher than the human health exposure expected from food use, or
Information to demonstrate that the chemical has been notified to the US FDA GRAS notification program and FDA had no questions about the notifier's conclusion of GRAS status, and that the human health exposure expected from the industrial use of the chemical is no higher than the human health exposure expected from food use, or
information that demonstrates that the chemical is a substance covered by Entry 9 of Annex V of the REACH Regulation or
test results that demonstrate the absence of mutagenic or genotoxic effects from both: - study on the chemical or from suitable read across information conducted following an acceptable test guideline for gene mutation, and - study on the chemical or from suitable read across information conducted following an acceptable test guideline for chromosomal abnormalities.
OECD Test 471: Bacterial Reverse Mutation Test OECD Test 473: In Vitro Mammalian Chromosomal Aberration Test OECD Test 474: Mammalian Erythrocyte Micronucleus Test OECD Test 475: Mammalian Bone Marrow Chromosomal Aberration Test OECD Test 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes OECD Test 478: Rodent Dominant Lethal Test OECD Test 485: Genetic toxicology, Mouse Heritable Translocation Assay OECD Test 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo OECD Test 487: In Vitro Mammalian Cell Micronucleus Test OECD Test 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays OECD Test 489: In Vivo Mammalian Alkaline Comet Assay OECD Test 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene |
Health info required for AICIS: 10 Skin corrosion | 08 November 2021
Test results from an in vitro study on the chemical or from suitable read across information, conducted following an acceptable test guideline for skin corrosion, with a non-corrosive prediction, or
test results from an in vitro study on the chemical or from suitable read across information, conducted following an acceptable test guideline for skin irritation, with a non-irritant prediction, or
test results from an in vivo study on the chemical or from suitable read across information, conducted following an acceptable test guideline for skin irritation, which does not result in destruction of skin tissue, as described for skin corrosion in chapter 3.2 of the GHS.
OECD Test 404: Acute Dermal Irritation/Corrosion OECD Test 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER) OECD Test 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method OECD Test 435: In Vitro Membrane Barrier Test Method for Skin Corrosion OECD Test 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method |
Health info required for AICIS: 11 Eye damage | 08 November 2021
Test results from an in vitro study on the chemical or from suitable read across information, conducted following an acceptable test guideline for eye damage, which predicts the chemical would not induce serious eye damage, or
test results from an in vivo study on the chemical or from suitable read across information, conducted following an acceptable test guideline for eye irritation, which does not result in effects on the eye, as described for eye damage in chapter 3.3 of the GHS
OECD Test 405: Acute Eye Irritation/Corrosion OECD Test 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage OECD Test 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage OECD Test 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants OECD Test 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage OECD Test 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage OECD Test 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage |
Health info required for AICIS: 12 Skin sensitisation | 08 November 2021
Test results from an in chemico test on the chemical or from suitable read-across information, conducted following an acceptable test guideline for the 1st key event in skin sensitisation, with a non-sensitising prediction; and
results from an in vitro study on the chemical or from suitable read across information, conducted following an acceptable test guideline for the 2nd key event in skin sensitisation, with a nonsensitising prediction; and
test results from an in vitro study on the chemical or from suitable read across information, conducted following an acceptable test guideline for the 3rd key event in skin sensitisation, with a non-sensitising prediction. OR
Test results from an in vivo study on the chemical or from suitable read-across information, conducted following an acceptable test guideline for skin sensitisation, which does not result in induction of an allergic response, as described in chapter 3.4 of the GHS.
OECD Test 406: Skin Sensitisation OECD Test 429: Skin Sensitisation OECD Test 442A: Skin Sensitization OECD Test 442B: Skin Sensitization OECD Test 442C: In Chemico Skin Sensitisation OECD Test 442D: In Vitro Skin Sensitisation OECD Test 442E: In Vitro Skin Sensitisation |
Health info required for AICIS: 13 Acute toxicity (fatal or toxic) | 08 November 2021
The chemical is permitted to be used as a food additive according to Schedule 15 of the Australia New Zealand Food Standards Code - Standard 1.3.1 - Food Additives, as long as the human health exposure expected from the industrial use of the chemical is no higher than the human health exposure expected from food use, or
a test result from at least one in vivo study on the chemical or from suitable read across information, as detailed below, with the administration route dependent on the most relevant route of exposure (or the oral route if information on the most relevant route is not available):
- conducted following an acceptable test guideline for acute oral toxicity with an LD50 greater than 300 mg/kg bw, or
- conducted following an acceptable test guideline for acute dermal toxicity with an LD50 greater than 1,000 mg/kg bw, or
- conducted following an acceptable test guideline for acute inhalation toxicity, with an LC50: - for gases - greater than 2,500 ppmV/4h, or - for vapours - greater than 10 mg/L/4h, or - for dusts/mists/fumes - greater than 1 mg/L/4h, or
test results from an in vivo study via the oral route on the chemical or from suitable read across information, conducted following an acceptable test guideline for subacute oral toxicity, with a NOAEL greater than or equal to 1,000 mg/kg bw/day
OECD Test 403: Acute Inhalation Toxicity OECD Test 420: Acute Oral Toxicity - Fixed Dose Procedure OECD Test 423: Acute Oral toxicity - Acute Toxic Class Method OECD Test 425: Acute Oral Toxicity: Up-and-Down Procedure OECD Test 433: Acute Inhalation Toxicity: Fixed Concentration Procedure OECD Test 436: Acute Inhalation Toxicity – Acute Toxic Class Method |
Health info required for AICIS: 14 STOT after repeated exposure: > 1,000 kg | 08 November 2021
A test result from at least one in vivo study on the chemical or from suitable read across information, as detailed below, with the administration route dependent on the most relevant route of exposure (or the oral route if information on the most relevant route is not available):
- conducted following an acceptable test guideline for subacute oral toxicity, in which the NOAEL (oral) is ≥300 mg/kg bw/day or there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or
- conducted following an acceptable test guideline for subchronic oral toxicity, in which the NOAEL (oral) is ≥100 mg/kg bw/day or there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or
- conducted following an acceptable test guideline for subacute dermal toxicity, in which the NOAEL (dermal) is ≥600 mg/kg bw/day or there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or
- conducted following an acceptable test guideline for subchronic dermal toxicity, in which the NOAEL (dermal) is ≥200 mg/kg bw/day or there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or
- conducted following an acceptable test guideline for subacute inhalation toxicity, in which there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or the NOAEC (inhalation) is: - for gases - ≥750 ppmV/6 h/day, or - for vapours - ≥3 mg/L/6 h/day, or - for dusts/mists/fumes - ≥0.6 mg/L/6 h/day, or
- conducted following an acceptable test guideline for subchronic inhalation toxicity, in which there were no significant toxic effects of relevance to human health (as described in chapter 3.9 of the GHS) produced, or the NOAEC (inhalation) is: - for gases - ≥250 ppmV/6 h/day, or - for vapours - ≥1 mg/L/6 h/day, or - for dusts/mists/fumes - ≥0.2 mg/L/6 h/day.
OECD Test 407: Repeated Dose 28-day Oral Toxicity Study in Rodents OECD Test 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents OECD Test 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents OECD Test 410: Repeated Dose Dermal Toxicity: 21/28-day Study OECD Test 411: Subchronic Dermal Toxicity: 90-day Study OECD Test 412: Subacute Inhalation Toxicity: 28-Day Study OECD Test 413: Subchronic Inhalation Toxicity: 90-day Study |
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